HSDD Treatments

Distressing low sexual desire, called hypoactive sexual desire disorder (HSDD) occurs in women and men. Currently, there are two FDA-approved medications for pre-menopausal women with generalized, acquired HSDD. This means that the woman once had normal desire and now it has lessened, it distresses her, and it occurs in all circumstnaces. These medications are often prescribed off-label for post-menopausal women and for men.


Flibanserin (trade name Addyi) is taken nightly to restore sexual desire to that experienced before the onset of HSDD. According to the label, it should not be taken within 2 hours of drinking alcohol, and 3 drinks or more were imbibed that evening dose should be skipped. The medication is in the class of MSAA, a multifunctional serotonin agonist and antagonist.


Bremelanotide (trade name Vyleesi) is an auto-filled injector the person injects prior to that time when the person wishes to experience desire. It can cause nausea when first used, but zofran may be taken concomittanlty to mitigate the nausea. The medication is a melanocortin.